The biggest downside, besides increased cost, is dealing with the connector. With plain cable you're free to 'abuse' the end of the wire as is necessary to get it pulled. Just don't over-stress the length as it's not too hard to break the conductors inside a longer length. If you pull 150 and it doesn't test true then having spent not-much-more on a 500' roll won't seem like a waste time-wise... just sayin'...
You mention conduit. Is this existing conduit or new? Is it going to share the same conduit as anything else, like AC electric? That being a no-no as far as signal reliability is concerned. You should generally avoid running low voltage digital lines directly in parallel with AC line voltage.
Pulling wire through conduit is never as easy as it "ought to be". That and take are about lubricants as not all are compatible with the insulating jackets on cabling (and this is often hard to determine with pre-made ones).
That and don't assume the conduit is going to remain water tight. Most don't, no matter how careful you try to be. This usually means it's a good idea to plan on using direct burial grade cable, even though it'll be in a conduit. "Belt and suspenders" as the saying goes. You don't want to have failures crop up requiring replacement. Better done right once than done again...
And, yes, like any internet forum topic, there's always the potential for more details than necessary, practical or affordable. Me, I prefer to err on the side of "don't make me do this again".