Yes, it should be able to be controlled via MediaCenter for diff zones (10 channels give 5 stereo independent or synched zones - MC11beta). therefore, MusicLobby (MainLobby) and Netremote should be able to use it just fine. Not aware of a MediaCenter plugin for Homeseer that can function with zones.
I use this card with my NR Nowplaying project. It has 5 independent zones using JRMC 10 and the Delta 410 card. I control all my audio equipment via Homeseer using a Slink-e. Not sure what you need to control on the sound card. Each pair of channels can be assigned to a zone within JRMC.