I use it on one of my MCE machines, so I could use an old Pinnacle PCTV remote instead of having to invest in a new MCE remote/transceiver. The other advantage is that by doing this, my HA setup knows when I push play/pause/stop (it relays the information to another Girder client on the HS machine), so it can dim the lights to the correct level.
I just started using it in my car, so I can use Voice Recognition, and will probably use it to monitor/control other aspects of my car (using relays, I/O boards, etc.).