Go simple with mission critical items. Yes, you can buy a system and devices that would equate to a second mortgage to control you HVAC, but the end result is going to be the same. Also, the more complex you make it, the harder it will be for others to service it or make the house less attractive in the event you choose to sell.
The only time you can really get away with a system like that would be in an ultra high end project where the installed systems are constantly under contract or PSA......I've done houses with zone dampers and controls for every room with essentially a commercial setup (pneumatics, VAV's and the like or electrics) with a BAS server.....it costs to play and keep it going. Does it look and function nicely, sure. Is it overkill, you bet. Would the average HO go out and buy a house/system like this? Never.