As both a CQC user and a Homeseer user, I can give you my 2 cents :unsure:
If you are interested in complete touchscreen control, and want it all in one package, then you should go with CQC. It also has a really great HA engine, plus it has many community members working hard to help anyone who needs it. So far, the thing that has impressed me the most is how easy it is to do some really cool things. I really expected to have to spend a lot of time learning things, but I was up and running within minutes. The video tutorials are also a great tool.
Main Lobby used to be just a front end, but from what I understand, they also have their own HA engine now. Main Lobby combined with Homeseer is a pretty powerful combination, but you will have rely on a plugin to establish the link between these 2 applications (not too big of a deal).
Price should not be an area of concern at this stage, since in the long run, you will end up spending about the same amount of money no matter what solution.