You could just about drive a truck through that amount of wood for a strike.
Something like a HES 8000 or 8300 would fit with room to spare. Same with a Securitron Unlatch.
Wiring would be run between the insulated panels straight down to the sill or up, depending on the wire route needed. Only hard part would be to get through the sill, usually aluminum or through the header. If you're dealing with getting through the sill, then using a 3/4" recessed contact usually would get you enough working room to be able to hit the hollow of the sidelite as well as get a decent angle to get through the sill with at least a 3/8" hole comfortably.
Between the inner skin and outer skin of the door there is a hollow that is filled with expanded foam insulation, really not that big a deal to get a wire route through for an 18/2 in this case once the strike area is made a standard ANSI prep. Depending on your 18/2 diameter, you could get away with a 1/4" hole through the foam, but I'd go 3/8 if I were to do it.
Only difficult part is getting the splice for the strike to go down the wire route/channel once all is said and done.