That's somewhat a matter of personal choice... How much further do you want to go in Home Automation? And have you decided on using other technologies like Z-Wave, Insteon or UPB?
A very popular option around here has been the Elk M1G because it's an awesome security controller and it has a lot of automation capabilities. I use mine for 90% of my automation because it's at the heart and can directly control everything in the house (sprinklers, garage doors, lights, hvac) and knows what's going on in the house - it knows if I'm home or not and what rooms we're in and what doors open - so it's easy to do automation based on things like if the garage door opens while the house is armed, turn on lights from the garage door to the kitchen.
With wireless, you have the option of Honeywell of GE sensors. One of the professional alarm installers on the board does offer up Honeywell as being his favorite; often GE was the most popular because their products are easier to find in certain distribution chains. Either will yield similar results in the end. A single receiver will handle 100+ contacts as long as they're in range; sometimes you need more than one depending on layout of the property but I'm covering a 4000sq ft house with a single one just fine.
Elk has a couple touchscreen options - and there are apps for iOS and Android that work great.
That said, the Vista 21P I believe to be a perfectly capable system with some automation capabilities - we just don't see nearly as much talk of it here. The Tuxedo is a nice out-of-box touch-screen solution, but I believe it's intended to be more of a closed eco-system, whereas working with things like Elk or HAI and the associated software is a completely open platform with limitless integration options.
Just my $.02 - others can certainly add other perspectives.